By Anne E. Desjardins "This book will be of great interest and value to plant pathologists as well as to veterinary and medical toxicologists as all these fields have been incorporated into this book. The fact that part "Literature Cited" counts 759 references shows how broad is the book subject." -- Journal of Plant Protection Research “…brings together most of the relevant available information to help
understand this important group of mycotoxigenic moulds… particularly useful to
undergraduate and post-graduate students to obtain the necessary knowledge on
this group of plant pathogens and spoilage moulds.” "This book has to find its way onto the shelves of everyone interested in
Fusarium toxins whether they be teachers, students, researchers or involved in
legislation and food safety and control, and it will also provide mycologists
with an insight into recent ideas about species concepts in this genus."
This comprehensive book examines the chemistry, genetics, and biology of Fusarium mycotoxins. It covers major and minor mycotoxins and other biologically active metabolites that can be harmful to both human and animal health. Past and present research is covered, providing both a historical concept on the topic, as well as guidelines for further research. Descriptions of Fusarium species assist in visual identification of species, while complete profiles will help assess risk as well give a background on geographic trends. And tables summarizing the distribution of mycotoxins among Fusarium species allow for quick reference to mycotoxins and Fusarium species. The book begins by presenting landmarks in the study of Fusarium mycotoxins from 1809 to 2005. These historical case studies and controversies document the relevance of mycotoxins to human and animal health. Also included is a thorough review of the molecular genetics of both trichothecene and fumonisin biosynthesis, presenting more than 15 years of molecular biological research in an accessible form. Part one then reviews the natural occurrence and toxicity of agriculturally important mycotoxins, with historical case studies of suspected mycotoxicoses in humans and animals. These chapters also contain updates on the molecular genetics of additional mycotoxins and the importance of mycotoxins in plant diseases. This useful reference presents concise descriptions of mycotoxin-producing Fusarium species, as defined by the most recent concepts of fungal species biology and evolution. Each species’ report includes a risk assessment based on its mycotoxin profile, occurrence in food and feed crops, and association with human and animal mycotoxicoses. Data on species distribution, mycotoxin profiles, and animal toxicity facilitate risk assessment for food and feed safety. This book will be of interest to agronomists, biological chemists, cereal chemists, food technologists, fungal geneticists, human nutritionists, international agricultural development agencies, molecular microbiologists, mycologists, plant breeders, plant pathologists, toxicologists, veterinary scientists, and advanced students in these fields. In addition, public health regulatory agencies that are interested in assessing and managing risks associated with Fusarium mycotoxins in food and feeds will find this an excellent resource. CONTENTSIntroduction to Fusarium Mycotoxicology Part One. Fusarium Mycotoxins Chapter 1. Trichothecenes Historical Case 1: Alimentary Toxic Aleukia in Russia and Central Asia Historical Case 2: Akakabi-byo in Japan Historical Case 3: Swine Feed Refusal in the Central United States Historical Case 4: The Yellow Rain Controversy Trichothecene Chemistry Overview of Trichothecene-Producing Fusarium Species Identification and Analysis of Trichothecenes Natural Occurrence of Trichothecenes In North America In South America In Europe In Africa In the Middle East and South Asia In East Asia In Southeast Asia, Australia, and New Zealand Trichothecene Genetics Trichothecene Biosynthetic Pathway Trichothecene Biosynthetic Enzymes Trichothecene Biosynthetic Genes Trichodiene Synthase (TR15) Cytochrome P450 Monoxygenases Trichodiene Oxygenase (TRI4) Isotrichodermin 15-Oxygenase (TRI11) Calonectrin 4-Oxygenase (TRI13 and YTRI13) Triacetoxyscirpenol 8-Oxygenase/Calonectrin 8-Oxyenase (TRI1) Enzymes that Add or Remove Ester Groups Trichothecene 15-O-Acetyltransferase (TRI3) Trichothecene 3-O-Acetyltransferase (TRI101) Trichothecene 3-O-Esterase (TRI8) Trichothecene 4-O-Acetyltransferase (TRI7 and YTRI7) Trichothecene 8-O-Acetyltransferase (TRI16 and YTRI16) Transcription Factors and Transporters Transcription Factor (TRI6) Trichothecene Transporter (TRI12) Regulatory Gene (TRI10) Transcripton Factor (TRI15) Coregulated Genes Trichothecene Biology Mechanism of Action of Trichothecenes Biological Activity of Trichothecenes in Animal Systems Biological Activity of Trichothcenes in Plant Systems Applications of Trichothecenes to Plant Breeding Chapter 2. Zearalenones Historical Case: Swine Estrogenic Syndrome in the Central United States Zearalenone Chemistry Overview of Zearalenone-Producing Fusarium Species Identification and Analysis of Zearalenones Natural Occurrence of Zearalenones In North America In South America In Europe In Africa In Asia In Australia and New Zealand Zearalenone Genetics Zearalenone Biosynthesis Zearalenone Biology Mechanism of Action of Zearalenones Biological Activity of Zearalenones in Animal Systems Biological Activity of Zearalenones in Plant Systems and Applications to Plant Breeding Chapter 3. Fumonisins Historical Case 1: Equine Leukoencephalomalacia in the United States Historical Case 2: Swine Pulmonary Edema in the Central United States Historical Case 3: Esophageal Cancer in South Africa Historical Case 4: Neural Tube Defects Along the Texas-Mexico Border Fumonisin Chemistry Overview of Fumonisin-Producing Fusarium Species Identification and Analysis of Fumonisins Natural Occurrence of Fumonisins In North America In South America In Europe In Africa In the Middle East and South Asia In East Asia In Southeast Asia and Australia Fumonisin Genetics Fumonisin Biosynthetic Pathway Fumonisin Biosynthetic Genes Polyketide Synthase (FUM1) C-3 Carbonyl Reductase (FUM13) Fumonisin 5-Oxygenase (FUM3) Tricarballylic Esterification (FUM7, FUM10, FUM11, and FUM14) Additional Required Genes in the FUM1 Gene Cluster Additional Coregulated Genes in the FUM1 Gene Cluster Fumonisin Biology Mechanism of Action of Fumonisins Biological Activity of Fumonisins in Animal Systems Biological Activity of Fumonisins in Plant Systems Applications of Fumonisins to Plant Breeding Chapter 4. Other Selected Mycotoxins Beauvericin Chemistry Genetics Biology Enniatins Chemistry Genetics Biology Fusaproliferin Chemistry Biology Fusaric Acids Chemistry Biology Fusarins Chemistry Biology Moniliformin Chemistry Genetics Biology Chapter 5. Other Selected Metabolites Acuminatum Butenolide Chlamydosporol Culmorin Cyclodepsipeptide HA23 Cyclonerodiol Equisetin Fusarochromanone Gibberellins Naphthoquinones Sambutoxin Wortmannin Part Two. Mycotoxigenic Fusarium Species Chapter 6. Selected Mycotoxigenic Fusarium Species Fusarium acuminatum and Fusarium armeniacum Fusarium acutatum Fusarium andiyazi Fusarium anthophilum Fusarum avenaceum, Fusarium aywerte, and Fusarium nurragi Fusarium begoniae Fusarium beomiforme Fusarium camptoceras Fusarium chlamydosporum Fusarium circinatum Fusarium compactum Fusarium concentricum Fusarium crookwellense (syn. Fusarium cerealis) Fusarium culmorum Fusarium denticulatum Fusarium dlamini Fusarium equiseti Fusarium fujikuroi Fusarium globosum Fusarium graminearum Fusarium guttiforme Fusarium konzum Fusarium kyushuense Fusarium lateritium Fusarium moniliforme (see Fusarium verticillioides) Fusarium napiforme Fusarium nygamai Fusarium oxysporum Fusarium phyllophilum Fusarium poae Fusarium proliferatum Fusarium pseudograminearum Fusarium sacchari Fusarium sambucinum Fusarium semitectum Fusarium solani Fusarium sporotrichioides Fusarium subglutinans Fusarium thapsinum Fusarium torulosum Fusarium tricinctum Fusarium venenatum Fusarium verticillioides Literature Cited Index
“…more than a twofold increase in toxin reports for Fusarium species since 1984. One of the greatest events in this period was the isolation and characterization of the most insidious and most highly carcinogenic Fusarium mycotoxin, fumonisin. These developments justify an authoritative new review of the whole topic, a mandate which the book admirably adopts…altogether this was a very successful production.”
“This is a true work of biological scholarship…an excellently written, authoritative, detailed and timely account of mycotoxins. They should command far greater attention as the importance of deficiencies in global food security become ever more apparent. She [author] is to be commended for the time successfully invested in writing this monograph. Biologists with other specialisms will find this a work worthy of their interest.”
“…a well structured, concise collection of up-to-date information on toxigenic species of Fusarium and their toxins… This book has to find its way onto the shelves of everyone interested in Fusarium toxins whether they be teachers, students, researchers or involved in legislation and food safety and control.”
“The topic, concept and contents of the book can be considered an extraordinarily interesting and up-to-date review of recent progress in the area of Fusarium mycotoxins."
"The general design of the book makes it an ideal reference text with a comprehensive bibliography and thorough index and as such would be ideal for any library...the book is compact and concise and very reasonably priced..." 2006; 6 x 9” hardcover; 260 pages; 27 black and white images;
ISBN 0-89054-335-6; (2 lbs.) |
return it within 30 days with a copy of your receipt for a full refund. © APS PRESS The American Phytopathological Society |